Amyloidosis: a rare cause of tongue swelling.

Vascular or lymphatic malformation can present as a diffuse tongue mass, suggested by a bluish hue or overlying vesicles. Tuberculosis, hypothyroidism, acromegaly, and idiopathic muscular hypertrophy manifest clinically as macroglossia, for which the diagnosis is aided by the medical history and other physical signs. Moreover, the nodular appearance of the macroglossia suggests other pathologies, such as granular sell tumour, neurogenic tumour, lipoma, fibroma, minor salivary gland tumour, and amyloidosis. Imaging might not be able to discriminate among these lesions and definite diagnosis often required biopsy.